Boc-(S)-3-甲酸哌啶合成路线 （共 16 条）
反应条件
1: 93 percent / Huenig base / CH2Cl2 / 0 deg C to RT 2: 100 percent / 4 N NaOH / tetrahydrofuran / 48 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 49, # 33 p. 7215 - 7222
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 2 h;
参考文献
US2006/4049 A1, ;
Page/Page column 49 ;
US 20060004049 A1
反应条件
1: With chloroformic acid ethyl ester; triethylamine in chloroform T=0°C; 0.166667 h; 2: With ammonia in chloroform T=20°C; 4 h;
参考文献
ADDEX PHARMACEUTICALS SA
Patent: WO2006/123257 A2, 2006 ;
Location in patent: Page/Page column 37; 50 ;
WO 2006/123257 A2
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h 1.2: 16 h 2.1: diethyl ether; tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
WO2011/117254 A1, ;
WO 2011/117254 A1
反应条件
1-methyl-piperidine; chloroformic acid ethyl ester in dichloromethane T=-78 - 20°C; 4.25 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/23258 A1, 2008 ;
Location in patent: Page/Page column 46-47 ;
WO 2008/023258 A1
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; Inert atmosphere;
参考文献
AMPLA PHARMACEUTICALS INC.; HAUSKE, James, R.
Patent: WO2010/120889 A1, 2010 ;
Location in patent: Page/Page column 45; 50 ;
WO 2010/120889 A1
