(R)-4-氯-3-羟基丁酸甲酯合成路线 （共 12 条）
反应条件
T=30°C; 24 h; Kroekera sp. No. 2201 (AKU 4705) growning in methanol; Yields of byproduct given;
参考文献
Ushio, Kazutoshi; Inouye, Kiyoko; Nakamura, Kaoru; Oka, Shinzaburo; Ohno, Atsuyoshi
Tetrahedron Letters, 1986 , vol. 27, # 23 p. 2657 - 2660
反应条件
N-chloro-succinimide; triphenylphosphine in dichloromethane T=5 - 20°C; 18.3333 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/21982 A2, 2007 ;
Location in patent: Page/Page column 67-68 ;
反应条件
Vigna unguiculata powder in water; isopropyl alcohol T=30°C; 48 h; optical yield given as percent eeenantioselective reaction;
参考文献
Bizerra, Ayla M.C.; Gonzalo, Gonzalo de; Lavandera, Ivan; Gotor-Fernandez, Vicente; de Mattos, Marcos Carlos; de Oliveira, Maria da Conceicao F.; Lemos, Telma L.G.; Gotor, Vicente
Tetrahedron Asymmetry, 2010 , vol. 21, # 5 p. 566 - 570
反应条件
halohydrin dehalogenase Trp249Phe mutant; Tris-SO4 buffer T=22°C; pH=7.5; 5 h;
参考文献
Elenkov, Maja Majeric; Tang, Lixia; Hauer, Bernhard; Janssen, Dick B.
Organic Letters, 2006 , vol. 8, # 19 p. 4227 - 4229
反应条件
Tris-HCl buffer T=30°C; pH=7.5; 24 h; Enzymatic reaction; enantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 74, # 4 p. 1730 - 1732
反应条件
1: methyl-4-chloroacetoacetate With isopropyl alcohol T=30°C; pH=7.5; 4 h; aq. bufferEnzymatic reaction; 2: sodium cyanide With halohydrin dehalogenase from Agrobacterium radiobacter AD1 T=30°C; pH=7.5; 44 h; aq. bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 14 p. 2293 - 2298
反应条件
sodium hydroxide; Enterobacter sp.DS-S-75 T=30°C; pH=6.7; 40 h; Enzymatic reaction; Product distribution; Further Variations:Reagents;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 4 p. 437 - 455
反应条件
1: With isopropyl alcohol T=30°C; 4 h; aq. bufferEnzymatic reaction; 2: With Agrobacterium radiobacter AD1 halohydrin dehalogenase HheC T=30°C; 20 h; aq. bufferEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 4 p. 483 - 488
反应条件
halohydrin dehalogenase Trp249Phe mutant; Tris-SO4 buffer in dimethyl sulfoxide T=22°C; pH=7.5; 1.5 h; Product distribution; Further Variations:Reagentsreaction times;
参考文献
Organic Letters, , vol. 8, # 19 p. 4227 - 4229
参考文献
Tetrahedron Asymmetry, , vol. 7, # 11 p. 3109 - 3112
