2-(1H-吡咯-1-基)异吲哚啉-1,3-二酮合成路线 （共 5 条）
反应条件
hydrazine hydrate in methanol 1 h; Heating;
参考文献
Dey, Sanjeev K.; Lightner, David A.
Journal of Organic Chemistry, 2007 , vol. 72, # 24 p. 9395 - 9397
反应条件
1: in 1,4-dioxane
Reflux;
2: With hydrogenchloride in 1,4-dioxane; water
参考文献
NEOPHARM CO., LTD.
Patent: US2011/183983 A1, 2011 ;
Location in patent: Page/Page column 23 ;
参考文献
Dae Woong Pharmaceutical Co., Ltd.
Patent: US5336673 A1, 1994 ;
反应条件
1: 57 percent / hydrazine sulfate; potassium bicarbonate / ethanol; H2O / 0.13 h / Heating
2: 75 percent / aq. HCl / dioxane / Heating
View Scheme
参考文献
Sanz, Dionisia; Perez-Torralba, Marta; Alarcon, Sergio Hugo; Claramunt, Rosa Maria; Foces-Foces, Concepcion; Elguero, Jose
Journal of Organic Chemistry, 2002 , vol. 67, # 5 p. 1462 - 1471
反应条件
hydrogen cation
Yield given;
参考文献
Jacobi, Peter A.; Buddhu, Subhas C.
Tetrahedron Letters, 1988 , vol. 29, # 38 p. 4823 - 4826
