oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 2.16667 h;
参考文献
McKittrick, Brian A.; Ma, Ke; Huie, Keith; Yumibe, Nathan; Davis Jr., Harry; Clader, John W.; Czarniecki, Michael; McPhail, Andrew T.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 752 - 759
1: 100 percent / aq. LiOH / tetrahydrofuran / Ambient temperature
2: (COCl)2, DMF / CH2Cl2 / 2.17 h / 0 - 20 °C
View Scheme
参考文献
McKittrick, Brian A.; Ma, Ke; Huie, Keith; Yumibe, Nathan; Davis Jr., Harry; Clader, John W.; Czarniecki, Michael; McPhail, Andrew T.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 752 - 759
1: 1.) NaH / 1.) DMF, 0 deg C, 15 min, 2.) DMF, from 0 deg C to RT 3 h
2: 100 percent / aq. LiOH / tetrahydrofuran / Ambient temperature
3: (COCl)2, DMF / CH2Cl2 / 2.17 h / 0 - 20 °C
View Scheme
参考文献
McKittrick, Brian A.; Ma, Ke; Huie, Keith; Yumibe, Nathan; Davis Jr., Harry; Clader, John W.; Czarniecki, Michael; McPhail, Andrew T.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 5 p. 752 - 759
