2-[3-(硼酸基)苯基]-2-甲基丙酸合成路线 （共 2 条）
反应条件
1: With tert.-butyl lithium in diethyl ether; pentane
T=-78°C; 0.5 h;
2: With tributoxyborane in diethyl ether; pentane
T=-78 - 20°C; 15 h;
3: With phosphoric acid; water in diethyl ether; pentane
参考文献
SANOFI-AVENTIS
Patent: WO2007/121280 A1, 2007 ;
Location in patent: Page/Page column 32 ;
WO 2007/121280 A1
反应条件
1: α-(3-bromophenyl)-α,α-dimethylacetic acid With tert.-butyl lithium in diethyl ether; pentane
T=-78°C; 0.5 h;
2: tributoxyborane in diethyl ether; pentane
T=20°C; 15 h;
3: With phosphoric acid; water in diethyl ether; pentane
参考文献
AVENTIS PHARMACEUTICALS INC
Patent: US2008/194600 A1, 2008 ;
Location in patent: Page/Page column 7 ;
