trimethylsilyl trifluoromethanesulfonate in acetonitrile T=30°C; 18 h;

trimethylsilyl trifluoromethanesulfonate in acetonitrile T=30 - 35°C; 18 h;

1: 90 percent / 37.5percent NaOH / H2O; benzene / 1 h / Ambient temperature 2: 49 percent / LDA / tetrahydrofuran / 2 h / -78 °C 3: 52 percent / trimethylsilyl triflate / acetonitrile / 18 h / 30 - 35 °C View Scheme

1: 49 percent / LDA / tetrahydrofuran / 2 h / -78 °C 2: 52 percent / trimethylsilyl triflate / acetonitrile / 18 h / 30 - 35 °C View Scheme