1.1: 75 percent / Al2O3; H2O / 20 h / 20 °C 2.1: 46 percent / pyridine / 16 h / 0 °C 3.1: 66 percent / Li2CuCl4 / tetrahydrofuran / 12 h / 20 °C 4.1: CuI / 16 h / 60 °C 4.2: Me2Cu(CN)(MgCl)2; DMPU / tetrahydrofuran / -78 - 0 °C View Scheme

1.1: BuLi / tetrahydrofuran / 3 h / 20 °C 1.2: 60 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 2 h / 0 °C 2.1: 87 percent / NaI / acetone / 48 h / Heating 3.1: CuI / 16 h / 60 °C 3.2: Me2Cu(CN)(MgCl)2; DMPU / tetrahydrofuran / -78 - 0 °C View Scheme

1.1: BuLi / tetrahydrofuran / 3 h / 20 °C 1.2: 85 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 2 h / 0 °C 2.1: 75 percent / Al2O3; H2O / 20 h / 20 °C 3.1: 46 percent / pyridine / 16 h / 0 °C 4.1: 66 percent / Li2CuCl4 / tetrahydrofuran / 12 h / 20 °C 5.1: CuI / 16 h / 60 °C 5.2: Me2Cu(CN)(MgCl)2; DMPU / tetrahydrofuran / -78 - 0 °C View Scheme

1.1: Amberlyst 15 / hexane / 3 h / 25 °C 2.1: tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / 0 - 25 °C 3.1: KF / dimethylformamide / 0.5 h / 55 °C 4.1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 4.2: 100 percent / tetrahydrofuran View Scheme

1.1: KF / dimethylformamide / 0.5 h / 55 °C 2.1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 2.2: 100 percent / tetrahydrofuran View Scheme

1.1: tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / 0 - 25 °C 2.1: KF / dimethylformamide / 0.5 h / 55 °C 3.1: n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C 3.2: 100 percent / tetrahydrofuran View Scheme