5-溴-2-氯-n-甲氧基-n-甲基烟酰胺合成路线 （共 6 条）
反应条件
methylmagnesium bromide in tetrahydrofuran T=0 - 20°C; 0.5 h; Inert atmosphere;
参考文献
Lin, Songwen; Han, Fangbin; Liu, Peng; Tao, Jing; Zhong, Xuechao; Liu, Xiujie; Yi, Chongqin; Xu, Heng
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 790 - 793
反应条件
in tetrahydrofuran T=-78°C; 3 h;
参考文献
AMGEN, INC.
Patent: WO2006/44860 A2, 2006 ;
Location in patent: Page/Page column 43-44 ;
WO 2006/044860 A2
反应条件
in tetrahydrofuran T=30°C; 0.5 h;
参考文献
Huart, Anne-Sophie; Saxty, Barbara; Merritt, Andy; Nekulova, Marta; Lewis, Stephen; Huang, Yide; Vojtesek, Borivoj; Kettleborough, Catherine; Hupp, Ted R.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5578 - 5585
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-10 - 20°C;
参考文献
PFIZER INC.
Patent: WO2009/16460 A2, 2009 ;
Location in patent: Page/Page column 104 ;
WO 2009/016460 A2
反应条件
1: 5-Bromo-2-chloro-3-pyridinecarboxylic acid With 1,1'-carbonyldiimidazole in dichloromethane
T=20°C; 1 h;
2: N,O-dimethyl-hydroxylamine in dichloromethane
T=20°C;
参考文献
PFIZER INC.
Patent: WO2009/16460 A2, 2009 ;
Location in patent: Page/Page column 102-104 ;
WO 2009/016460 A2
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C;
参考文献
Lin, Songwen; Han, Fangbin; Liu, Peng; Tao, Jing; Zhong, Xuechao; Liu, Xiujie; Yi, Chongqin; Xu, Heng
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 790 - 793
