(6-氯-吡啶-3-基)-2-丙酮合成路线 （共 3 条）
反应条件
in tetrahydrofuran; diethyl ether
T=20°C; 1 h; Cooling with iceInert atmosphere;
参考文献
TAISHO PHARMACEUTICAL CO., LTD; Kuwada, Takeshi; Yoshinaga, Mitsukane; Ishizaka, Tomoko; Wakasugi, Daisuke; Shirokawa, Shin-ichi; Hattori, Nobutaka; Shimazaki, Youichi; Miyakoshi, Naoki
Patent: US2013/197217 A1, 2013 ;
Location in patent: Paragraph 0576; 0577; 0578 ;
反应条件
sodium acetate
T=75 - 80°C; 11 h;
参考文献
Tanaka; Ito; Nishino; Motoyama; Takasugi
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 12 p. 3206 - 3213
反应条件
1: EDC monohydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 96 h / 20 °C
2: tetrahydrofuran; diethyl ether / 1 h / 20 °C / |Cooling with ice; |Inert atmosphere
View Scheme
参考文献
TAISHO PHARMACEUTICAL CO., LTD; Kuwada, Takeshi; Yoshinaga, Mitsukane; Ishizaka, Tomoko; Wakasugi, Daisuke; Shirokawa, Shin-ichi; Hattori, Nobutaka; Shimazaki, Youichi; Miyakoshi, Naoki
Patent: US2013/197217 A1, 2013 ;
