4-氨基-4'-氯-[1,1'-联苯]-3-羧酸合成路线 （共 2 条）
反应条件
1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 0.17 h / 200 °C
2: lithium hydroxide hydrate / tetrahydrofuran / 20 °C
3: trifluoroacetic acid / dichloromethane
View Scheme
参考文献
Steinmetz, Heinrich; Zander, Wiebke; Shushni, Muftah A.M.; Jansen, Rolf; Gerth, Klaus; Dehn, Richard; Draeger, Gerald; Kirschning, Andreas; Mueller, Rolf
ChemBioChem, 2012 , vol. 13, # 12 p. 1813 - 1817
反应条件
1: tetrahydrofuran / 72 h / Reflux
2: bromine; sodium acetate; acetic acid / 14 h
3: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 0.17 h / 200 °C
4: lithium hydroxide hydrate / tetrahydrofuran / 20 °C
5: trifluoroacetic acid / dichloromethane
View Scheme
参考文献
Steinmetz, Heinrich; Zander, Wiebke; Shushni, Muftah A.M.; Jansen, Rolf; Gerth, Klaus; Dehn, Richard; Draeger, Gerald; Kirschning, Andreas; Mueller, Rolf
ChemBioChem, 2012 , vol. 13, # 12 p. 1813 - 1817
