八氢-2,7-萘啶-2(1h)-羧酸叔丁酯合成路线 （共 5 条）
反应条件
hydrogen; palladium(II) oxide hydrate; acetic acid
T=80°C;
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
Location in patent: Paragraph 00363 ;
反应条件
1: trichlorophosphate / 24 h / 180 °C
2: potassium acetate; hydrogen; palladium on activated charcoal / methanol / 24 h / 20 °C
3: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 0 - 20 °C
4: acetic acid; hydrogen; palladium(II) oxide hydrate / 80 °C
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1.1: ethylamine / ethanol / 48 h / 20 °C
1.2: 0.17 h / 100 °C
2.1: trichlorophosphate / 24 h / 180 °C
3.1: potassium acetate; hydrogen; palladium on activated charcoal / methanol / 24 h / 20 °C
4.1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 0 - 20 °C
5.1: acetic acid; hydrogen; palladium(II) oxide hydrate / 80 °C
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1: potassium acetate; hydrogen; palladium on activated charcoal / methanol / 24 h / 20 °C
2: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 0 - 20 °C
3: acetic acid; hydrogen; palladium(II) oxide hydrate / 80 °C
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 0 - 20 °C
2: acetic acid; hydrogen; palladium(II) oxide hydrate / 80 °C
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
