反应条件
1: formaldehyd; ortho-bromo-phenol With triethylamine; magnesium chloride in tetrahydrofuran
T=75°C; 4 h;
2: acrylonitrile With 1,4-diaza-bicyclo[2.2.2]octane
T=95°C; 18 h;
3: With water; sodium hydroxide
T=100°C; 4 h;
参考文献
SCHERING CORPORATION; MCCORMICK, Kevin D.; DONG, Li; BOYCE, Christopher W; DE LERA RUIZ, Manuel; FEVRIER, Salem; WU, Jie; ZHENG, Junying; YU, Younong; CHAO, Jianhua; WON, Walter S.; RAO, Ashwin U.; KUANG, Rongze; TING, Pauline C.; HUANG, Xianhai; SHAO, Ning; PALANI, Anandan; BERLIN, Michael Y.; ASLANIAN, Robert G.
Patent: WO2010/42473 A1, 2010 ;
Location in patent: Page/Page column 130 ;
WO 2010/042473 A1