[2-(4-氟-苯基)-噁唑-4-基]-甲醇合成路线 （共 5 条）
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C; 3 h;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby
Patent: WO2011/88187 A1, 2011 ;
Location in patent: Page/Page column 52 ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; toluene
T=-10 - 20°C; 3 h;
2: With ammonium chloride in tetrahydrofuran; toluene
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby
Patent: WO2011/88187 A1, 2011 ;
Location in patent: Page/Page column 52 ;
反应条件
acetyl chloride in methanol
T=0 - 20°C; 3.08 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: US2009/170907 A1, 2009 ;
Location in patent: Page/Page column 53 ;
反应条件
1.1: dibenzoyl peroxide / benzene / 0.25 h / Reflux
1.2: 2 h / Reflux
2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -10 - 20 °C
View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby
Patent: WO2011/88187 A1, 2011 ;
反应条件
1.1: dichloromethane / 24 h / 0 - 20 °C
2.1: dibenzoyl peroxide / benzene / 0.25 h / Reflux
2.2: 2 h / Reflux
3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -10 - 20 °C
View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby
Patent: WO2011/88187 A1, 2011 ;
