1: 1.) diisopropylamine, butyllithium / 1.) THF, hexanes, -70 deg C, 30 min, 2.) THF, hexanes, from -70 deg C to RT 2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 2.) THF, -30 deg C View Scheme

lithium diisopropyl amide 1.) THF, -78 deg C, 2.) THF, -30 deg C; Multistep reaction;

lithium hydroxide in tetrahydrofuran; methanol; water