2-(2-甲氧基苯基)-噻唑-4-甲醛合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-40 - -10°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 132 - 135
反应条件
1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C 2: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C 3: potassium carbonate / acetone / |Reflux 4: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 132 - 135
反应条件
1: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C 2: potassium carbonate / acetone / |Reflux 3: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 132 - 135
反应条件
1: potassium carbonate / acetone / |Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 132 - 135
反应条件
1: methanol; aq. phosphate buffer / 60 °C / pH 6.4 2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C 3: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C 4: potassium carbonate / acetone / |Reflux 5: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 132 - 135
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=-40 - -10°C;
参考文献
Noel, Sabrina; Hoegy, Francoise; Rivault, Freddy; Rognan, Didier; Schalk, Isabelle J.; Mislin, Gaetan L.A.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 132 - 135
反应条件
1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
2: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C
3: potassium carbonate / acetone / |Reflux
4: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C
View Scheme
参考文献
Noel, Sabrina; Hoegy, Francoise; Rivault, Freddy; Rognan, Didier; Schalk, Isabelle J.; Mislin, Gaetan L.A.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 132 - 135
反应条件
1: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C
2: potassium carbonate / acetone / |Reflux
3: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C
View Scheme
参考文献
Noel, Sabrina; Hoegy, Francoise; Rivault, Freddy; Rognan, Didier; Schalk, Isabelle J.; Mislin, Gaetan L.A.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 132 - 135
反应条件
1: potassium carbonate / acetone / |Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C
View Scheme
参考文献
Noel, Sabrina; Hoegy, Francoise; Rivault, Freddy; Rognan, Didier; Schalk, Isabelle J.; Mislin, Gaetan L.A.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 132 - 135
反应条件
1: methanol; aq. phosphate buffer / 60 °C / pH 6.4
2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
3: trichloromonobromomethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 20 °C
4: potassium carbonate / acetone / |Reflux
5: lithium aluminium tetrahydride / tetrahydrofuran / -40 - -10 °C
View Scheme
参考文献
Noel, Sabrina; Hoegy, Francoise; Rivault, Freddy; Rognan, Didier; Schalk, Isabelle J.; Mislin, Gaetan L.A.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 132 - 135
