1-[3-(苯甲酰氧基)丙基]-2,3-二氢-5-[(2R)-2-[[2-[2-(2,2,2-三氟乙氧基)苯氧基]乙基]氨基]丙基]-1H-吲哚-7-甲腈合成路线 （共 3 条）
反应条件
in water; isopropyl alcohol
参考文献
KISSEI PHARMACEUTICAL CO., LTD.
Patent: WO2006/46499 A1, 2006 ;
Location in patent: Page/Page column 11-12 ;
反应条件
water; sodium hydroxide in methanol T=20°C; 1.25 h; cooling with ice;
参考文献
RATIOPHARM GMBH; GIDWANI, Ramesh Matioram; KOLHATKAR, Mayur Vilas
Patent: WO2011/124704 A1, 2011 ;
Location in patent: Page/Page column 24 ;
反应条件
1: water; sodium hydroxide / methanol / 2 h / 20 °C 2: water; sodium hydroxide; dihydrogen peroxide / dimethyl sulfoxide / 2.25 h / 20 °C View Scheme
参考文献
SANDOZ AG; KUMAR LUTHRA, Parven; BHUTA, Sachin; ABHINAY, Chandrakant Pise; DATTATRAYA, N., Chavan; SHASHIKANT, D., Metkar
Patent: WO2013/56842 A1, 2013 ;
