1: With triethylamine; isobutyl chloroformate in tetrahydrofuran
T=-15°C; 1 h;
2: With sodium azide in tetrahydrofuran; water
T=20°C; Curtius Rearrangement;
3: With hydrogenchloride; water
more than 3 stages;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2007/125321 A2, 2007 ;
Location in patent: Page/Page column 123-124 ;
WO 2007/125321 A2
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2006/46024 A1, 2006 ;
Location in patent: Page/Page column 126 ;
WO 2006/046024 A1
