乙基7-氯-6-氟-1-[甲酰基(甲基)氨基]-4-氧代-1,4-二氢-3-喹啉羧酸酯合成路线 （共 12 条）
反应条件
sodium hydride in N,N-dimethyl-formamide
T=140°C; 3.5 h;
参考文献
Chu
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1033 - 1034
反应条件
potassium carbonate in N,N-dimethyl-formamide
1.5 h; Ambient temperature;
参考文献
Wentland; Bailey; Cornett; Dobson; Powles; Wagner
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1103 - 1108
反应条件
sodium hydride in 1,4-dioxane
1. 10 min., room temp. 2. 2.5 h, reflux;
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 871 - 880
反应条件
1: 78 percent / K2CO3, O-(2,4-dinitrophenyl)hydroxylamine / dimethylformamide / 3 h / Ambient temperature
2: 1.) acetic anhydride / 1.) 0-50 deg C, 30 min, 2.) 25 deg C, 3.5 d
3: 90 percent / K2CO3 / dimethylformamide / 1.5 h / Ambient temperature
View Scheme
参考文献
Wentland; Bailey; Cornett; Dobson; Powles; Wagner
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1103 - 1108
反应条件
1: 1.) acetic anhydride / 1.) 0-50 deg C, 30 min, 2.) 25 deg C, 3.5 d
2: 90 percent / K2CO3 / dimethylformamide / 1.5 h / Ambient temperature
View Scheme
参考文献
Wentland; Bailey; Cornett; Dobson; Powles; Wagner
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1103 - 1108
反应条件
1: 80 percent / NaH / 1.5 h / 80 °C
2: 1) acetic anhydride / 1) 130 deg C, 1.5 h; 2) CH2Cl2, 1.5 h
3: 82 percent / NaH / dimethylformamide / 3.5 h / 140 °C
View Scheme
参考文献
Chu
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1033 - 1034
反应条件
1: 1) acetic anhydride / 1) 130 deg C, 1.5 h; 2) CH2Cl2, 1.5 h
2: 82 percent / NaH / dimethylformamide / 3.5 h / 140 °C
View Scheme
参考文献
Chu
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1033 - 1034
反应条件
1: 88 percent / ethanol / 1 h / Ambient temperature
2: 84 percent / 80percent NaH / dioxane / 1. 10 min., room temp. 2. 2.5 h, reflux
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 871 - 880
反应条件
1: 91 percent / NaOH / H2O / 2 h / Heating
2: 65 percent / pyridine / 15 h / Heating
View Scheme
参考文献
Chu
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1033 - 1034
反应条件
hydrogenchloride in acetonitrile
T=90°C; 7 h;
参考文献
Chu
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1033 - 1034
