乙基7-氯-6-氟-1-[甲酰基(甲基)氨基]-4-氧代-1,4-二氢-3-喹啉羧酸酯合成路线 （共 12 条）
反应条件
1: 91 percent / NaOH / H2O / 2 h / Heating
2: 65 percent / pyridine / 15 h / Heating
3: 82 percent / 1.) 0.1N NaOH, 30percent H2O2, 2.) 10percent Pd/C / 1.) 45 deg C, 20 h, 2.) 25 deg C, 1 h
View Scheme
参考文献
Wentland; Bailey; Cornett; Dobson; Powles; Wagner
Journal of Medicinal Chemistry, 1984 , vol. 27, # 9 p. 1103 - 1108
反应条件
1: 91 percent / NaOH / H2O / 2 h / Heating
2: 75 percent / pyridine / 15 h / Heating
View Scheme
参考文献
Grohe, Klaus; Heitzer, Helmut
Liebigs Annalen der Chemie, 1987 , p. 871 - 880
