1-Boc-3,6-二氢-2H-吡啶-5-硼酸频哪醇酯合成路线 （共 3 条）
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=80°C; 16 h;
参考文献
Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; Meegalla, Sanath K.; Rudolph, M. Jonathan; Wall, Mark J.; Wilson, Kenneth J.; Desjarlais, Renee L.; Manthey, Carl L.; Molloy, Christopher J.
Patent: US2008/51402 A1, 2008 ;
Location in patent: Page/Page column 60 ;
US 20080051402 A1
反应条件
1: (tert-Butoxycarbonyl)piperidin-3-one With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.333333 h; 2: With N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran T=0°C; 3 h; 3: 4,4,5,5-tetramethyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,2-dioxaborolane
参考文献
WO2011/143495 A1, ;
Page/Page column 85 ;
WO 2011/143495 A1
反应条件
1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0.5 h / -78 °C 1.2: 20 °C 2.1: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) chloride acetone complex / 1,4-dioxane / 12 h / 80 °C View Scheme
参考文献
WO2011/29046 A1, ;
WO 2011/029046 A1
