5-氨基-1-boc-3,4,5,6-四氢-2H-[2,4]联吡啶合成路线 （共 4 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=760.051 Torr; 18 h;
参考文献
Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; Meegalla, Sanath K.; Rudolph, M. Jonathan; Wall, Mark J.; Wilson, Kenneth J.; Desjarlais, Renee L.; Manthey, Carl L.; Molloy, Christopher J.
Patent: US2008/51402 A1, 2008 ;
Location in patent: Page/Page column 70 ;
US 20080051402 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethanol 20.5 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/147831 A1, 2008 ;
Location in patent: Page/Page column 47 ;
WO 2008/147831 A1
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; toluene / 0.67 h / 100 °C / Inert atmosphere; Microwave irradiation 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 2 h / 2585.81 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 7 p. 2433 - 2446
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / ethanol; toluene / 0.67 h / 100 °C / Inert atmosphere; Microwave irradiation 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 2 h / 2585.81 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 7 p. 2433 - 2446
