E-3-(4-苄氧基)-1-(2.4-二苄氧基-6-羟基)苯基)丙烯酮合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate Ambient temperatureatmospheric pressure;
参考文献
Jain, A. C.; Paliwal, Poonam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 416 - 418
反应条件
1.1: 76 percent / I2 / dimethylsulfoxide / 24 h / 110 °C 2.1: DMSO; 3 Angstroem molecular sieves / acetone; CH2Cl2 / -20 - 0 °C 2.2: 50 percent / TsOH*H2O / CH2Cl2 / 1 h / 20 °C 3.1: 85 percent / PPh3 / Pd2(dba)3*CHCl3 / CH2Cl2 / 3 h / 0 °C 4.1: 73 percent / NaBH4 / CH2Cl2; methanol / 3 h / -78 °C 5.1: 96 percent / OsO4; NMO / acetone; 2-methyl-propan-2-ol; H2O / 3 h / 0 °C 6.1: 80 percent / H2 / Pd/C / tetrahydrofuran; ethanol / 3 h / 20 °C View Scheme
参考文献
Shan, Mingde; O'Doherty, George A.
Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
反应条件
iodine in dimethyl sulfoxide T=110°C; 24 h;
参考文献
Shan, Mingde; O'Doherty, George A.
Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
反应条件
1.1: 76 percent / I2 / dimethylsulfoxide / 24 h / 110 °C 2.1: DMSO; 3 Angstroem molecular sieves / acetone; CH2Cl2 / -20 - 0 °C 2.2: 50 percent / TsOH*H2O / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Maloney, David J.; Hecht, Sidney M.
Organic Letters, 2005 , vol. 7, # 6 p. 1097 - 1099
反应条件
1: 1.3 g / H2 / 10percent Pd-C / ethyl acetate / Ambient temperature; atmospheric pressure
2: 295 mg / BF3*Et2O, DMF / 1.5 h / Heating
View Scheme
参考文献
Jain, A. C.; Paliwal, Poonam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 416 - 418
反应条件
1.1: 76 percent / I2 / dimethylsulfoxide / 24 h / 110 °C
2.1: DMSO; 3 Angstroem molecular sieves / acetone; CH2Cl2 / -20 - 0 °C
2.2: 50 percent / TsOH*H2O / CH2Cl2 / 1 h / 20 °C
3.1: 85 percent / PPh3 / Pd2(dba)3*CHCl3 / CH2Cl2 / 3 h / 0 °C
4.1: 73 percent / NaBH4 / CH2Cl2; methanol / 3 h / -78 °C
5.1: 96 percent / OsO4; NMO / acetone; 2-methyl-propan-2-ol; H2O / 3 h / 0 °C
6.1: 86 percent / DMAP; pyridine / CH2Cl2 / 0 °C
7.1: 86 percent / H2 / Pd/C / tetrahydrofuran; ethanol / -90 - 20 °C
View Scheme
参考文献
Shan, Mingde; O'Doherty, George A.
Organic Letters, 2006 , vol. 8, # 22 p. 5149 - 5152
反应条件
1.1: 76 percent / I2 / dimethylsulfoxide / 24 h / 110 °C
2.1: DMSO; 3 Angstroem molecular sieves / acetone; CH2Cl2 / -20 - 0 °C
2.2: 50 percent / TsOH*H2O / CH2Cl2 / 1 h / 20 °C
3.1: 85 percent / PPh3 / Pd2(dba)3*CHCl3 / CH2Cl2 / 3 h / 0 °C
4.1: 73 percent / NaBH4 / CH2Cl2; methanol / 3 h / -78 °C
5.1: 156 mg / pyridine; DMAP / CH2Cl2 / 1 h / 0 °C
6.1: 77 percent / OsO4; NMO / 2-methyl-propan-2-ol; H2O / 24 h / 0 °C
7.1: p-TsOH*H2O / CH2Cl2 / 0.25 h / 0 °C
7.2: 99 percent / aq. HOAc / CH2Cl2 / 0.25 h / 0 °C
8.1: 62 percent / DBU / toluene / 1 h / 0 °C
9.1: 91 percent / DBU / toluene / 1 h / 0 °C
View Scheme
参考文献
Maloney, David J.; Hecht, Sidney M.
Organic Letters, 2005 , vol. 7, # 6 p. 1097 - 1099
反应条件
Multi-step reaction with 3 steps 1.1: 72 percent / I2 / dimethylsulfoxide / 140 °C2.1: DMDO / CH2Cl2; acetone / 0 °C2.2: 78 percent Turnov. / pTsOH / CH2Cl2 / 0.5 h / 0 °C3.1: 60 percent / Ag2O / CH2Cl2 / 4 h / 20 °C
参考文献
Maloney, David J.; Hecht, Sidney M. Organic Letters, 2005 , vol. 7, # 6 p. 1097 - 1099
