N-(5-氧代-5,6,7,8-四氢萘酚-2-基)乙酰胺合成路线 （共 8 条）
参考文献
WO2008/76336 A2, ;
Page/Page column 78 ;
WO 2008/076336 A2
反应条件
chromium(VI) oxide; acetic anhydride in acetic acid
参考文献
Journal of Medicinal Chemistry, , vol. 19, # 4 p. 472 - 475
反应条件
1.1: thionyl chloride / nitromethane / 1 h / Cooling with ice 2.1: AlCl3, aluminium chloride / nitromethane / 0.5 h / 20 °C 2.2: Cooling with ice View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 18 p. 5539 - 5552
反应条件
1.1: nitric acid / 2 h / Cooling with ice 2.1: palladium 10 on activated carbon; hydrogen; acetic acid / 3 h / 20 °C / 3000.3 Torr 2.2: 4 h / 3000.3 Torr 3.1: pyridine / 1 h / 20 °C 4.1: thionyl chloride / nitromethane / 1 h / Cooling with ice 5.1: AlCl3, aluminium chloride / nitromethane / 0.5 h / 20 °C 5.2: Cooling with ice View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 18 p. 5539 - 5552
反应条件
1.1: palladium 10 on activated carbon; hydrogen; acetic acid / 3 h / 20 °C / 3000.3 Torr 1.2: 4 h / 3000.3 Torr 2.1: pyridine / 1 h / 20 °C 3.1: thionyl chloride / nitromethane / 1 h / Cooling with ice 4.1: AlCl3, aluminium chloride / nitromethane / 0.5 h / 20 °C 4.2: Cooling with ice View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 18 p. 5539 - 5552
反应条件
sulfuric acid T=90°C;
参考文献
Harris III, Ralph N.; Stabler, Russel S.; Repke, David B.; Kress, James M.; Walker, Keith A.; Martin, Renee S.; Brothers, Julie M.; Ilnicka, Mariola; Lee, Simon W.; Mirzadegan, Tara
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 11 p. 3436 - 3440
反应条件
1: 25percent aq. HBr / 2 h / Heating 2: CuBr, NaNO2, 48percent HBr / H2O / 1 h / 0 °C View Scheme
参考文献
Giardina; Clarke; Dondio; Petrone; Sbacchi; Vecchietti
Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3482 - 3491
反应条件
1: 80 percent / NaOH / H2O / 3 h / Ambient temperature 2: 71 percent / Zn, AcOH / H2O / 0.5 h / 100 °C 3: 91 percent / H2NNH2*H2O / ethanol / 3 h / Heating 4: 85 percent / 4 N HCl / 2 h / 100 °C 5: 72 percent / toluene / 6 h / Heating View Scheme
参考文献
Cignarella; Barlocco; Pinna; Loriga; Curzu; Tofanetti; Germini; Cazzulani; Cavalletti
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2277 - 2282
