乙基4-氧代-4H-喹嗪-3-羧酸酯合成路线 （共 4 条）
反应条件
1: 2-picoline With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes T=-78 - -60°C; 0.5 h; Inert atmosphere; 2: diethyl 2-ethoxymethylenemalonate in tetrahydrofuran; hexanes T=-60 - -20°C; Inert atmosphere; 3: in xylenes 16 h; Reflux;
参考文献
Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780
反应条件
in diphenylether; ethanol; hexane; chloroform
反应条件
nitric acid; acetic anhydride
参考文献
Xu, Yi-Sheng; Zeng, Cheng-Chu; Jiao, Zi-Guo; Hu, Li-Ming; Zhong, Ru-Gang
Molecules, 2009 , vol. 14, # 2 p. 868 - 883
反应条件
trichlorophosphate Vilsmeier formylation; 1 h; regioselective reaction;
参考文献
Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780
