3-[3,4-二(乙酰氧基)苯基]-2-丙烯酸合成路线 （共 6 条）
反应条件
1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / toluene / 3 h / 90 °C / |Inert atmosphere 2: pyrrolidine / tetrahydrofuran / 0.5 h / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 75, p. 391 - 402
反应条件
1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / toluene / 3 h / 90 °C / |Inert atmosphere
2: pyrrolidine / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Rodrigues, Nuno; Bennis, Khalil; Vivier, Delphine; Pereira, Vanessa; Chatelain, Franck C.; Chapuy, Eric; Deokar, Hemantkumar; Busserolles, Jerome; Lesage, Florian; Eschalier, Alain; Ducki, Sylvie
European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 391 - 402
反应条件
1: Et3N / tetrahydrofuran
2: Et3N / tetrahydrofuran / Ambient temperature
3: 3percent aq. Na2CO3 / ethanol / 2 h / Heating
View Scheme
参考文献
Tseng; Iwakami; Mikajiri; Shibuya; Hanaoka; Ebizuka; Padmawinata; Sankawa
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 2 p. 396 - 400
反应条件
potassium carbonate in acetone
T=25°C; 8 h;
参考文献
Barontini, Maurizio; Bernini, Roberta; Carastro, Isabella; Gentili, Patrizia; Romani, Annalisa
New Journal of Chemistry, 2014 , vol. 38, # 2 p. 809 - 816
参考文献
Freudenberg; Heel
Chemische Berichte, 1953 , vol. 86, p. 186,193
反应条件
tetrachloromethane; phosphorus pentachloride
beim Hydrieren des Reaktionsprodukts (F: 161grad) an Palladium/BaSO4 in Xylol und Erwaermen des danach erhaltenen mit Kaliumacetat in Aethanol;
参考文献
Buecking,W.
Diss. <Leipzig 1928> S. 61, 63
