(E)-6-硝基-3-[2-(吡啶-2-基)乙烯基]-1-(四氢-2H-吡喃-2-基)-1H-吲唑合成路线 （共 4 条）
反应条件
N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide
T=100°C; 12 h;
参考文献
CURIS, INC.
Patent: WO2009/36066 A1, 2009 ;
Location in patent: Page/Page column 52 ;
WO 2009/036066 A1
反应条件
1: potassium carbonate; iodine / N,N-dimethyl-formamide / 25 °C
2: methanesulfonic acid / dichloromethane; tetrahydrofuran / 5 h / 25 °C
3: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 12 h / 100 °C
View Scheme
参考文献
CURIS, INC.
Patent: WO2009/36066 A1, 2009 ;
WO 2009/036066 A1
反应条件
1: methanesulfonic acid / dichloromethane; tetrahydrofuran / 5 h / 25 °C
2: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 12 h / 100 °C
View Scheme
参考文献
CURIS, INC.
Patent: WO2009/36066 A1, 2009 ;
WO 2009/036066 A1
反应条件
iron; ammonium chloride in ethanol; water
T=50°C; 2 - 8 h;
参考文献
PFIZER INC.
Patent: WO2006/48761 A2, 2006 ;
Location in patent: Page/Page column 31-32 ;
WO 2006/048761 A2
