1-(4-溴苯基)-1-(4-甲氧基苯基)甲胺合成路线 （共 5 条）
反应条件
potassium hydroxide in methanol
T=175°C; 6 h;
参考文献
MERCK SHARP and DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun
Patent: WO2013/40790 A1, 2013 ;
Location in patent: Page/Page column 32 ;
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 16 h / 20 °C / |Inert atmosphere
2: 6 h / 175 °C
3: potassium hydroxide / methanol / 6 h / 175 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun
Patent: WO2013/40790 A1, 2013 ;
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 16 h / 20 °C / |Inert atmosphere
2: 6 h / 175 °C
3: potassium hydroxide / methanol / 6 h / 175 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun
Patent: WO2013/40790 A1, 2013 ;
反应条件
1: 6 h / 175 °C
2: potassium hydroxide / methanol / 6 h / 175 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun
Patent: WO2013/40790 A1, 2013 ;
反应条件
1: thionyl chloride / 3 h / 20 °C
2: AlCl3, aluminium chloride / dichloromethane / 16 h / 20 °C / |Inert atmosphere
3: 6 h / 175 °C
4: potassium hydroxide / methanol / 6 h / 175 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ZHOU, Changyou; ZOU, Wuxin; HUA, Yuxia; DANG, Qun
Patent: WO2013/40790 A1, 2013 ;
