1-(5-溴-2-吡啶基)-2,2,2-三氟乙酮合成路线 （共 3 条）
反应条件
1: 2,5-dibromo-pyridine With n-butyllithium in hexanes; toluene
T=-78°C; 0.5 h;
2: TFETFA in hexanes; toluene
T=-78°C; 2.25 h;
3: With water; ammonium chloride in hexanes; toluene
参考文献
MERCK FROSST CANADA LTD.
Patent: WO2006/133559 A1, 2006 ;
Location in patent: Page/Page column 38 ;
WO 2006/133559 A1
反应条件
1: 2,5-dibromo-pyridine With n-butyllithium in tetrahydrofuran; hexane; toluene
T=-78°C;
2: ethyl-α,α,α-trifluoroacetate in tetrahydrofuran; hexane; toluene
T=-78°C; 0.5 h;
参考文献
Curtis, Michael; Duclos, Brian A.; Ewin, Richard A.; Johnson, Paul D.; Johnson, Timothy Allen; Vairagoundar, Rajendran; Billen, Denis; Goodwin, Richard M.; Haber-Stuk, Andrea K.; Kyne, Graham M.; Sheehan, Susan M. K.
Patent: US2013/237502 A1, 2013 ;
Location in patent: Paragraph 0397 ;
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C
1.2: 4 h
2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 18 h / |Reflux
View Scheme
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
