5-溴-4-甲基吡啶-2-羧酸合成路线 （共 5 条）
反应条件
potassium permanganate in water; acetone T=20°C; 72 h;
参考文献
Hoffmann-La Roche Inc.; Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Bhagirath, Niala; Kennedy-Smith, Joshua; Wilhelm, Robert Stephen
Patent: US2013/158049 A1, 2013 ;
Location in patent: Paragraph 0168 ;
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=20°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=4;
参考文献
WO2012/143329 A1, ;
Page/Page column 142-143 ;
WO 2012/143329 A1
反应条件
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether; water / 4 h / 100 °C 2: potassium permanganate / water; acetone / 72 h / 20 °C View Scheme
反应条件
1.1: thionyl chloride / 2 h / Reflux 2.1: water; lithium hydroxide hydrate / tetrahydrofuran; methanol / 1 h / 20 °C 2.2: pH 4 View Scheme
参考文献
WO2012/143329 A1, ;
WO 2012/143329 A1
反应条件
sulfuric acid 14 h; Reflux;
参考文献
Hoffmann-La Roche Inc.; Alam, Muzaffar; Du Bois, Daisy Joe; Hawley, Ronald Charles; Bhagirath, Niala; Kennedy-Smith, Joshua; Wilhelm, Robert Stephen
Patent: US2013/158049 A1, 2013 ;
Location in patent: Paragraph 0169 ;
