1-(4-氯-2-氟苯基)-2,2,2-三氟乙酮合成路线 （共 2 条）
反应条件
1: 4-chloro-2-fluoro-1-iodobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h; Inert atmosphere;
2: ethyl-α,α,α-trifluoroacetate in tetrahydrofuran; hexane
T=20°C;
参考文献
Connolly, Peter J.; Macielag, Mark J.; Zhu, Bin
Patent: US2012/58986 A1, 2012 ;
Location in patent: Page/Page column 31 ;
US 20120058986 A1
反应条件
1: 4-chloro-2-fluoro-1-iodobenzene With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 1 h; Inert atmosphere;
2: trifluoro acetic acid methyl ester in tetrahydrofuran; hexanes
T=-78 - 20°C;
参考文献
Zhang, Yue-Mei; Connolly, Peter J.; Lin, Shu-Chen; MacIelag, Mark J.
Patent: US2012/101081 A1, 2012 ;
Location in patent: Page/Page column 33 ;
