6-氯-2-氟-3-甲氧基苯甲酸合成路线 （共 2 条）
反应条件
1: 4-chloro-2-fluoro-1-methoxybenzene With n-butyllithium in tetrahydrofuran
T=-78°C; 0.5 h;
2: carbon dioxide in tetrahydrofuran
T=-78 - 20°C;
3: With hydrogenchloride; water
pH=~ 1;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/71736 A1, 2008 ;
Location in patent: Page/Page column 54 ;
WO 2008/071736 A1
反应条件
boron tribromide in dichloromethane
T=0 - 20°C; Product distribution / selectivity;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRADL, Stefan; LAIRD, Ellen; MORENO, David; REN, Li; WENGLOWSKY, Steven Mark
Patent: WO2011/25968 A1, 2011 ;
Location in patent: Page/Page column 44; 45 ;
WO 2011/025968 A1
