2-(3,5-二氟苯基)吡咯烷合成路线 (共 1 条)
反应条件
1.1: diisobutylaluminium hydride / diethyl ether / 1 h / 0 °C / |Inert atmosphere
1.2: 25 h / -78 °C / |Inert atmosphere
2.1: thionyl chloride / ethylene glycol dimethyl ether / 3 h / 0 - 25 °C
2.2: 4 h / 0 - 25 °C
View Scheme
参考文献
Ramachandran, P. Veeraraghavan; Mitsuhashi, Wataru; Nicponski, Daniel R.
Tetrahedron Letters, 2013 , vol. 54, # 37 p. 5001 - 5003