反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 120 °C
2.1: hydrogen / 5 palladium on charcoal / methanol / 20 °C
3.1: sodium nitrite; sulfuric acid / ethylene glycol dimethyl ether; water / 0.83 h / 0 - 5 °C
3.2: 0.5 h / 0 °C
View Scheme
参考文献
PURDUE PHARMA .LP.; KYLE, Donald, J.; NI, Chiyou; PARK, Minnie; TAFESSE, Laykea
Patent: WO2012/7836 A1, 2012 ;
WO 2012/007836 A1