1: With lithium diisopropyl amide in tetrahydrofuran T=-78 - 20°C; 2: With water; ammonium chloride in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water pH=5;

1.1: 95 percent / methanol 2.1: lithium diisopropylamide; triisopropyl borate / tetrahydrofuran / -78 - 0 °C 2.2: 95 percent / hydrochloric acid / tetrahydrofuran; H2O / 20 °C View Scheme

dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in toluene T=100°C; 1.5 h;

dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in toluene T=100°C; 2 h;