1-(4-氟苯基)-5-甲基-1H-1,2,3-噻唑-4-羧酸合成路线 （共 5 条）
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran T=20°C; 18 h; 2: With citric acid in tetrahydrofuran T=0 - 5°C; pH=3 - 4;
参考文献
PROTEOSTASIS THERAPEUTICS, INC.
Patent: US2012/316193 A1, 2012 ;
Location in patent: Page/Page column 49 ;
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-1(2)-ene in tert-butyl alcohol T=20°C; 0.666667 h; Inert atmosphere;
参考文献
WO2009/105746 A2, ;
Page/Page column 77 ;
反应条件
sodium methylate in methanol
参考文献
Obushak; Pokhodylo; Pidlypnyi; Matiichuk
Russian Journal of Organic Chemistry, 2008 , vol. 44, # 10 p. 1522 - 1527
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C 1.2: 1 h / 20 °C 2.1: diethylamine / dimethyl sulfoxide / 18 h / 70 °C / Inert atmosphere 3.1: water; lithium hydroxide hydrate / tetrahydrofuran / 18 h / 20 °C 3.2: 0 - 5 °C / pH 3 - 4 View Scheme
反应条件
1.1: diethylamine / dimethyl sulfoxide / 18 h / 70 °C / Inert atmosphere 2.1: water; lithium hydroxide hydrate / tetrahydrofuran / 18 h / 20 °C 2.2: 0 - 5 °C / pH 3 - 4 View Scheme
