反应条件
1: phosphonoacetic acid P,P-bis(2,2,2-trifluoroethyl)methyl ester With potassium tert-butylate in tetrahydrofuran
T=0°C; Inert atmosphere;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Risgaard, Rune; Nielsen, Simon D.; Hansen, Kasper B.; Jensen, Christina M.; Nielsen, Birgitte; Traynelis, Stephen F.; Clausen, Rasmus P.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 10 p. 4071 - 4081