(1-甲基环己烷基)甲基-4-氨基苯基醚合成路线 （共 5 条）
反应条件
copper(I) oxide; hydrogenchloride; sodium nitrite 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C; Yield given. Multistep reaction;
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
1: 1.) NaNO2, 47percent HBr, 2.) Cu2O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C 2: 2.) 2N HCl / 1.) sulfolane, 110 deg C, 2 h; 2.) sulfolane, reflux, 8 h View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
hydrogen; palladium on activated charcoal in methanol
P=760 Torr; Ambient temperature;
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
1: 86.9 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C
2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
1: 86.9 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C
2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
