反应条件
1.1: sodium hydride / mineral oil; toluene / 16.5 h / |Reflux
2.1: N,N-dimethyl-formamide / 5 h / |Reflux; |Inert atmosphere
2.2: 1 h / |Reflux
3.1: acetic acid; hydrogenchloride / water / 5 h / |Reflux
View Scheme
参考文献
Hanan, Emily J.; Van Abbema, Anne; Barrett, Kathy; Blair, Wade S.; Blaney, Jeff; Chang, Christine; Eigenbrot, Charles; Flynn, Sean; Gibbons, Paul; Hurley, Christopher A.; Kenny, Jane R.; Kulagowski, Janusz; Lee, Leslie; Magnuson, Steven R.; Morris, Claire; Murray, Jeremy; Pastor, Richard M.; Rawson, Tom; Siu, Michael; Ultsch, Mark; Zhou, Aihe; Sampath, Deepak; Lyssikatos, Joseph P.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10090 - 10107