6-溴-8-甲硫基咪唑并[1,2-A]吡嗪合成路线 （共 4 条）
参考文献
Belanger, David B.; Curran, Patrick J.; Hruza, Alan; Voigt, Johannes; Meng, Zhaoyang; Mandal, Amit K.; Siddiqui, M. Arshad; Basso, Andrea D.; Gray, Kimberly
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5170 - 5174
反应条件
in methanol
T=20°C; 2 h;
参考文献
Schering Corporation
Patent: US2007/105864 A1, 2007 ;
Location in patent: Page/Page column 175 ;
US 20070105864 A1
反应条件
N-iodo-succinimide in N,N-dimethyl-formamide
T=60°C; 6.5 h; Inert atmosphere;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; KLAR, Ulrich; KOPPITZ, Marcus; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; PRECHTL, Stefan; NGUYEN, Duy; SCOTT, William
Patent: WO2011/113862 A1, 2011 ;
Location in patent: Page/Page column 55-56 ;
WO 2011/113862 A1
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide
T=100°C;
参考文献
Voss, Matthew E.; Rainka, Matthew P.; Fleming, Mike; Peterson, Lisa H.; Belanger, David B.; Siddiqui, M. Arshad; Hruza, Alan; Voigt, Johannes; Gray, Kimberly; Basso, Andrea D.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3544 - 3549
