(2-氯-吡啶-4-基)乙酸合成路线 （共 3 条）
反应条件
hydrogenchloride; water
18 h; Reflux;
参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
Location in patent: Page/Page column 31 ;
US 20110224225 A1
反应条件
1: With methanol; water; sodium hydroxide
2 h; Reflux;
2: With hydrogenchloride in water
pH=4 - 5;
参考文献
NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD.; BURNS, Christopher, J.; GOSWAMI, Rajesh; JACKSON, Randy, W.; LESSEN, Thomas; LI, Weiping; PEVEAR, Daniel; TIRUNAHARI, Pavan, Kumar; XU, Hongyu
Patent: WO2010/130708 A1, 2010 ;
Location in patent: Page/Page column 107 ;
WO 2010/130708 A1
反应条件
1: potassium hydride / 0 - 20 °C
2: hydrogenchloride; water / 18 h / Reflux
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参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
US 20110224225 A1
