1-苯基-4-三甲基锡-3-丁炔-2-酮合成路线 （共 6 条）
反应条件
AlCl3, aluminium chloride in dichloromethane
T=0°C; 0.5 h;
参考文献
Pankova, Alena S.; Golubev, Pavel R.; Kuznetsov, Mikhail A.; Ananyev, Ivan V.
European Journal of Organic Chemistry, 2012 , # 30 p. 5965 - 5971,7
反应条件
sulfuric acid in water; acetone
5 h; Heating;
参考文献
Kruithof, Klaas J. H.; Schmitz, Robert F.; Klumpp, Gerhard W.
Tetrahedron, 1983 , vol. 39, # 19 p. 3073 - 3082
反应条件
1: 81 percent / p-toluenesulfonic acid / benzene / Heating
2: 1.) BuLi / 1.) THF, -65 deg C, 30 min; 2.) THF, overnight, -65 deg C to 25 deg C
3: 67 percent / H2SO4 / acetone; H2O / 5 h / Heating
View Scheme
参考文献
Kruithof, Klaas J. H.; Schmitz, Robert F.; Klumpp, Gerhard W.
Tetrahedron, 1983 , vol. 39, # 19 p. 3073 - 3082
反应条件
1: 1.) BuLi / 1.) THF, -65 deg C, 30 min; 2.) THF, overnight, -65 deg C to 25 deg C
2: 67 percent / H2SO4 / acetone; H2O / 5 h / Heating
View Scheme
参考文献
Kruithof, Klaas J. H.; Schmitz, Robert F.; Klumpp, Gerhard W.
Tetrahedron, 1983 , vol. 39, # 19 p. 3073 - 3082
反应条件
1: 1.) THF, EtMgBr, RT, 1 h; 2.) diethyl ether, -25 deg C for 45 min then 1 h at RT then 15 min at 30 deg C
2: 81 percent / p-toluenesulfonic acid / benzene / Heating
3: 1.) BuLi / 1.) THF, -65 deg C, 30 min; 2.) THF, overnight, -65 deg C to 25 deg C
4: 67 percent / H2SO4 / acetone; H2O / 5 h / Heating
View Scheme
参考文献
Kruithof, Klaas J. H.; Schmitz, Robert F.; Klumpp, Gerhard W.
Tetrahedron, 1983 , vol. 39, # 19 p. 3073 - 3082
反应条件
1: thionyl chloride / dichloromethane / Reflux
2: AlCl3, aluminium chloride / dichloromethane / 0 °C
View Scheme
参考文献
Menendez, Christophe; Gau, Sylvain; Lherbet, Christian; Rodriguez, Frederic; Inard, Cyril; Pasca, Maria Rosalia; Baltas, Michel
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5524 - 5531
