5-甲基-3-噻吩甲酸甲酯合成路线 （共 3 条）
反应条件
1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine in dimethyl sulfoxide T=70°C; P=1551.49 Torr;
参考文献
ELI LILLY AND COMPANY; LEDGARD, Andrew, James
Patent: WO2013/32804 A1, 2013 ;
Location in patent: Page/Page column 6 ;
反应条件
1: sodium hydroxide; water / methanol / 0.75 h / 65 °C 2: acetic acid; bromine / 1 h / 20 °C View Scheme
参考文献
ELI LILLY AND COMPANY; LEDGARD, Andrew, James
Patent: WO2013/32804 A1, 2013 ;
反应条件
water; sodium hydroxide in methanol T=65°C; 0.75 h;
参考文献
ELI LILLY AND COMPANY; LEDGARD, Andrew, James
Patent: WO2013/32804 A1, 2013 ;
Location in patent: Page/Page column 6; 7 ;
