potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;

phosphoric acid in hexane

n-butyllithium in tetrahydrofuran; hexane T=-60°C; Flow reactor;

1: 1-bromo-4-(difluoromethoxy)benzene With n-butyllithium in diethyl ether; hexane T=-60°C; 1 h; 2: tri-isopropoxy-borane in diethyl ether; hexane T=-60 - 20°C; 2 h; 3: With phosphoric acid in diethyl ether; hexane; water T=10°C; 1 h;

1.1: potassium hydroxide / acetonitrile; water / 0.08 h / 0 °C 1.2: 0 - 20 °C 2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 20 - 80 °C / Inert atmosphere View Scheme