7-甲氧基苯并[b]噻吩-2-羧酸合成路线 （共 14 条）
反应条件
sodium hydroxide in water T=100°C; 1 h;
参考文献
Rahman, Loay K. A.; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2973 - 2978
反应条件
in water 8 h; Heating;
参考文献
Rahman, Loay K. A.; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2973 - 2978
反应条件
1: 85 percent / KOH / tetrahydrofuran; H2O / 0.17 h / Ambient temperature 2: 90 percent / diphenyl ether / 0.25 h / 240 - 250 °C 3: 1.) aq. NaOH / 1.) Ph2O, 100 deg C, 6 h, 2.) H2O, reflux View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 2973 - 2978
反应条件
1: 90 percent / diphenyl ether / 0.25 h / 240 - 250 °C 2: 1.) aq. NaOH / 1.) Ph2O, 100 deg C, 6 h, 2.) H2O, reflux View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 2973 - 2978
反应条件
1: 90 percent / NaOH / methanol; H2O / 1 h / Heating 2: 90 percent / H2O / 8 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 2973 - 2978
反应条件
1: 90 percent / H2O / 4 h / Heating 2: 100 percent / lNaOH / H2O / 1 h / 100 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 2973 - 2978
反应条件
sodium hydroxide 1.) Ph2O, 100 deg C, 6 h, 2.) H2O, reflux; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 2973 - 2978
反应条件
quinoline; copper T=210 - 220°C; 1.5 h; Inert atmosphere;
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
Location in patent: Page/Page column 144 ;
反应条件
1: 70 percent / copper bronze / quinoline / 2 h / 210 - 220 °C
2: 55 percent / BBr3 / CH2Cl2 / Ambient temperature
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/41275 A1, 2004 ;
Location in patent: Page/Page column 27 ;
WO 2004/041275 A1
反应条件
hydrogen bromide in acetic acid
5 h; Heating;
参考文献
Rahman, Loay K. A.; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2973 - 2978
