7-甲氧基苯并[b]噻吩-2-羧酸合成路线 （共 14 条）
反应条件
1: 70 percent / copper bronze / quinoline / 2 h / 210 - 220 °C
2: 55 percent / BBr3 / CH2Cl2 / Ambient temperature
3: 87 percent / K2CO3 / butan-2-one / 3 h / Heating
View Scheme
参考文献
Rahman, Loay K. A.; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2973 - 2978
反应条件
1: 70 percent / copper bronze / quinoline / 2 h / 210 - 220 °C
2: 55 percent / BBr3 / CH2Cl2 / Ambient temperature
3: 87 percent / K2CO3 / butan-2-one / 3 h / Heating
4: 74 percent / N.N-dimethylaniline / 6 h / Heating
View Scheme
参考文献
Rahman, Loay K. A.; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2973 - 2978
反应条件
1: 70 percent / copper bronze / quinoline / 2 h / 210 - 220 °C
2: 92 percent / Br2 / CCl4 / 1.5 h / 0 °C
View Scheme
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
反应条件
1: 70 percent / copper bronze / quinoline / 2 h / 210 - 220 °C
2: 81 percent / HNO3, glacial AcOH / acetic acid / 1 h / 0 °C
View Scheme
参考文献
Rahman, Loay K. A.; Scrowston, Richard M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2973 - 2978
