7-甲氧基-1-苯并噻吩合成路线 （共 21 条）
反应条件
PPA in chlorobenzene T=145 - 155°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/43904 A1, 2004 ;
Location in patent: Page 33 ;
WO 2004/043904 A1
反应条件
quinoline; copper T=210 - 220°C; 1.5 h; Inert atmosphere;
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
Location in patent: Page/Page column 144 ;
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol Heating;
参考文献
Mukherjee, Chandrani; Kamila, Sukanta; De, Asish
Tetrahedron, 2003 , vol. 59, # 26 p. 4767 - 4774
反应条件
potassium carbonate in acetone 8 h; Heating;
参考文献
Samanta, Subhendu Sekhar; Ghosh, Sukhen Chandra; De, Asish
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 24 p. 3673 - 3677
反应条件
phosphoric acid; phosphorus pentoxide T=170°C; P=15 Torr;
参考文献
Proceedings - Indian Academy of Sciences, Section A, , # 33 p. 35,40
反应条件
1: 98 percent / K2CO3 / dimethylformamide 2: 45 percent / PPA / 145 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 21 p. 5395 - 5399
反应条件
1.1: sec-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C 1.2: 85 percent / tetrahydrofuran; cyclohexane / -78 - 20 °C 2.1: 69 percent / LDA / tetrahydrofuran / -78 - 20 °C 3.1: 71 percent / NaBH4; NaOH / methanol; H2O / 13 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 26 p. 4767 - 4774
反应条件
1: 69 percent / LDA / tetrahydrofuran / -78 - 20 °C 2: 71 percent / NaBH4; NaOH / methanol; H2O / 13 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 59, # 26 p. 4767 - 4774
反应条件
1: 85 percent / KOH / tetrahydrofuran; H2O / 0.17 h / Ambient temperature 2: 90 percent / diphenyl ether / 0.25 h / 240 - 250 °C 3: 1.) aq. NaOH / 1.) Ph2O, 100 deg C, 6 h, 2.) H2O, reflux 4: 70 percent / copper bronze / quinoline / 2 h / 210 - 220 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 2973 - 2978
反应条件
1: 90 percent / diphenyl ether / 0.25 h / 240 - 250 °C 2: 1.) aq. NaOH / 1.) Ph2O, 100 deg C, 6 h, 2.) H2O, reflux 3: 70 percent / copper bronze / quinoline / 2 h / 210 - 220 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 12 p. 2973 - 2978
