3,5-二苯基-1,2,4-恶二唑合成路线 （共 159 条）
反应条件
1: CH3ONa / methanol / 1.5 h
2: 41 percent / CH2Cl2
3: 97 percent / 0.08 h / 210 °C
View Scheme
参考文献
Smith, Richard F.; Coffman, Karen J.; Geer, Susan M.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 69 - 71
反应条件
1: 62 percent / acetonitrile / 24 h / Ambient temperature
2: CH3ONa / methanol / 1.5 h
3: 41 percent / CH2Cl2
4: 97 percent / 0.08 h / 210 °C
View Scheme
参考文献
Smith, Richard F.; Coffman, Karen J.; Geer, Susan M.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 69 - 71
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 4 h / 20 °C / |Inert atmosphere
2: triethylamine / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / |Inert atmosphere
3: potassium phosphate; oxygen / N,N-dimethyl-formamide / 1.5 h / 100 °C / 760.05 Torr
View Scheme
参考文献
Zhang, Feng-Lian; Wang, Yi-Feng; Chiba, Shunsuke
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 36 p. 6003 - 6007
反应条件
1: triethylamine / N,N-dimethyl-formamide / 6 h / 0 - 20 °C / |Inert atmosphere
2: potassium phosphate; oxygen / N,N-dimethyl-formamide / 1.5 h / 100 °C / 760.05 Torr
View Scheme
参考文献
Zhang, Feng-Lian; Wang, Yi-Feng; Chiba, Shunsuke
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 36 p. 6003 - 6007
参考文献
Beckmann
Chemische Berichte, 1889 , vol. 22, p. 1591,1594
反应条件
hydroxylamine in methanol
Heating;
参考文献
Baccar,B.-G.; Mathis,F.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1965 , vol. 261, p. 174 - 177
反应条件
triethylamine in 1,2-dichloro-ethane
6 h;
参考文献
Blake, Alexander J.; Gould, Robert O.; McGhie, Karen E.; Paton, R. Michael; Reed, David; et al.
Carbohydrate Research, 1991 , vol. 216, # 1 p. 461 - 474
反应条件
1: 20 percent / triethylamine / dioxane / Ambient temperature
2: 100 percent / xylene / 0.5 h / Heating
View Scheme
参考文献
Plenkiewicz, Jan; Zdrojewski, Tadeusz
Bulletin des Societes Chimiques Belges, 1981 , vol. 90, # 2 p. 193 - 194
反应条件
1: 20 percent / triethylamine / dioxane / Ambient temperature
2: 100 percent / xylene / 0.5 h / Heating
View Scheme
参考文献
Plenkiewicz, Jan; Zdrojewski, Tadeusz
Bulletin des Societes Chimiques Belges, 1981 , vol. 90, # 2 p. 193 - 194
反应条件
1: 40 percent / toluene-p-sulphonyl chloride, pyridine / 48 h / Ambient temperature
2: 91 percent / N-chlorosuccinimide / CH2Cl2 / 2 h
3: ethanol / Heating
View Scheme
参考文献
Ooi, Ngan Sim; Wilson, David A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 1792 - 1799
