(5-甲基噁唑-2-基)甲醇合成路线 （共 4 条）
反应条件
1: With methanol; sodium hydroxide; water
T=20°C; 0.5 h;
2: With hydrogenchloride in methanol; water
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1813603 A1, 2007 ;
Location in patent: Page/Page column 38 ;
EP 1813603 A1
反应条件
methanol; sodium tetrahydroborate
T=0 - 20°C;
参考文献
NOVARTIS AG; BOCK, Mark Gary; LAGU, Bharat; PANDIT, Chetan; SASMAL, Sanjita; ULLRICH, Thomas
Patent: WO2013/128421 A1, 2013 ;
Location in patent: Page/Page column 87; 88 ;
反应条件
1: Dess-Martin periodane / dichloromethane / 0 - 20 °C
2: trichlorophosphate / toluene / 16 h / 20 °C / |Reflux
3: methanol; sodium tetrahydroborate / 0 - 20 °C
View Scheme
参考文献
NOVARTIS AG; BOCK, Mark Gary; LAGU, Bharat; PANDIT, Chetan; SASMAL, Sanjita; ULLRICH, Thomas
Patent: WO2013/128421 A1, 2013 ;
反应条件
1: trichlorophosphate / toluene / 16 h / 20 °C / |Reflux
2: methanol; sodium tetrahydroborate / 0 - 20 °C
View Scheme
参考文献
NOVARTIS AG; BOCK, Mark Gary; LAGU, Bharat; PANDIT, Chetan; SASMAL, Sanjita; ULLRICH, Thomas
Patent: WO2013/128421 A1, 2013 ;
