4-(3-羟基丙基)-1H-咪唑-1-羧酸叔丁酯合成路线 (共 3 条)
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in 1,4-dioxane; water; acetonitrile
2 h; Ambient temperature;
参考文献
Krause; Ligneau; Stark; Garbarg; Schwartz; Schunack
Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4171 - 4176
反应条件
LiAlH4 in tetrahydrofuran; water
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
triethylamine in 1,4-dioxane; water
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4452791 A1, 1984 ;
US 4452791 A