1H-吡咯并[2,3-b]吡啶-4-甲胺合成路线 （共 2 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=40°C; 1 h;
参考文献
Wang, Xin; Zhi, Ben; Baum, Jean; Chen, Ying; Crockett, Richard; Huang, Liang; Eisenberg, Shawn; Ng, John; Larsen, Robert; Martinelli, Mike; Reider, Paul
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 4021 - 4023
反应条件
1.1: 89.2 percent / 1,2-dimethoxy-ethane; heptane / 2.5 h / 20 °C
2.1: POCl3 / 18 h / 85 - 90 °C
2.2: 12.28 kg / Zn; dppf / Pd2dba3 / N,N-dimethyl-acetamide / 2 h / 120 °C
3.1: 74 percent / LAH / tetrahydrofuran / 1 h / 40 °C
View Scheme
参考文献
Wang, Xin; Zhi, Ben; Baum, Jean; Chen, Ying; Crockett, Richard; Huang, Liang; Eisenberg, Shawn; Ng, John; Larsen, Robert; Martinelli, Mike; Reider, Paul
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 4021 - 4023
